A subject I've been banging on about for a while is white tigers. They can only be genetically created through severe insest. Only one case has ever been found in the wild and all other white tigers in existance have been bred in captivity with alarming results. They are bred purely for the entertainment industry and zoo's. Because of the genetic gene pool many are born mentally and psyically disabled and are kept away from the public in apauling conditions. Please read more here
there have also been a number of cases in the news about people being kept in captivity. Being locked up for years without natural light affects the skin colour. the same way the scrambled genes in the tigers drain their coats of their natural colour. Thus me looking at loss of colour.
I'm currently working on developing these ideas into a project.